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KMID : 1161420140170060686
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Journal of Medicinal Food
2014 Volume.17 No. 6 p.686 ~ p.693
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Analgesic and Anti-Inflammatory Activities of the 2,8-Dihydroxy-1,6-Dimethoxyxanthone from Haploclathra paniculata (Mart) Benth (Guttiferae)
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Moreira Maria Eliza Castro
Pereira Rosemary Gualberto Fonseca Alvarenga
Silva Marcelo Jose Dias
Dias Danielle Ferreira
Gontijo Vanessa Silva
Giusti-Paiva Alexandre
Veloso Marcia Paranho
Doriguetto Antonio Carlos
Nagem Tanus Jorge
dos Santos Marcelo Henrique
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Abstract
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In the present study, the pharmacological effects of 2,8-dihydroxy-1,6-dimethoxyxanthone from the bark of Haploclathra paniculata were investigated in mice using in vivo inflammation and nociception models. Acetic acid-induced writhing, paw licking induced by formalin, hot plate, and carrageenan-induced paw edema tests were used to investigate the anti-inflammatory and antinociceptive activities of the xanthone compound. Xanthone, at both doses, inhibited abdominal writhing and the formalin test. At a dose of 20?mg/kg, the time of reaction to the hot plate increased, and significant effects were observed after 30, 60 and 90?min of treatment. At doses of 10 and 20?mg/kg p.o., the 2,8-dihydroxy-1,6-dimethoxyxanthone significantly reduced paw edema at 3?h after the stimulus. The tests also showed no acute toxicity of the xanthone compound in mice. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability was also studied and confirmed the antioxidant activity of the xanthone. To propose the mechanism of action of anti-inflammatory activity of the xanthone, a molecular docking was performed using the isoenzymes cyclooxygenase 1 and 2 and the results indicate that the molecule is capable of inhibiting both the enzymes. Therefore, it can be concluded that 2,8-dihydroxy-1,6-dimethoxyxanthone from H. paniculata demonstrates analgesic, anti-inflammatory, and antioxidant activities.
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KEYWORD
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analgesic effect, anti-inflammatory activity, DPPH, edema, inflammation, oxygenated xanthone
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